The better solution to arrive
in Montepulciano is to use the italian Highway
A1. You must search for the exit Bettole-Val
di Chiana , and you take the direction for Torrita of Siena
and after exit from Torrita, on the left, you must follow the
Montepulciano indications( only 15-20 minutes).
Also, If you come from Siena, you
must drive for Siena-Bettolle with
A1 direction and you must exit to Sinalunga. You must continued
in Torrita direction and after for Montepulciano.